The shrine to tequila near El Gran Malo's entrance should give you some indication as to how seriously this bar takes its spirits. Its signature tequila infusions range from fruits and vegetables (strawberry-cucumber or blueberry-jalapeño-cilantro) to herbs and spices (cinnamon-vanilla or hops) and even meats (a beef jerky-infused tequila makes a great Bloody Maria), each of them making a fascinating twist on the margarita. If a more mainstream margarita is your speed, El Gran Malo has more than 40 excellent tequilas to choose from — none of which are infused with anything except agave.