Most video game characters have understandable weaknesses. Bullets kill you. Lava burns you. When a Hunter comes flying at you with its claws extended and it connects with your neck your head goes flying across the rooms exactly as heads shouldn't. We get that.
Then again, some games pick some very arbitrary kryptonites to inflict on their people. It can be tough to toe the line between believability and just making sure that a character advances the story or level as the designers intended, but damn some of this comes out of left field.