7. "Vogue": When "Vogue" topped the Dance/Club Play chart for two weeks in 1990, Madonna was indisputably the biggest female recording artist in the world -- the reigning Queen of Pop. The disco-inflected house single also shot to No. 1 on the Billboard Hot 100 on its way to selling over six million copies.
In many ways, "Vogue" represents the high-water mark of Madonna's career. If you've never danced to this song, you've never been dancing. Madonna most recently performed "Vogue" live at this year's Super Bowl halftime show.
6. "Hung Up": "Hung Up" represented something of a comeback for Madonna after her disappointing American Life album was greeted mostly with curled lips in 2003. Two years later, she was back on top thanks to this disco-heavy track featuring a prominent sample from ABBA's "Gimme! Gimme! Gimme! (A Man After Midnight)." "Hung Up" went to No. 1 on charts in 41 countries, earning a spot in the 2007 Guinness Book of World Records. It spent four weeks atop the U.S. club chart.
5. "Express Yourself": Madonna's great liberation anthem was a club smash, topping the Dance/Club Play chart for three weeks in 1989. "Express Yourself" is a big, brassy exhortation for women to either demand the best from their relationships or walk away -- Madonna's answer to Aretha Franklin's "Respect."
The song received at least as much airplay on MTV as it did in the club thanks to an iconic video directed by David Fincher that saw the pop star stretch and bend feminist conceptions of power and sexuality to shock and titillate her audience. Basically, an instant classic.
4. "What It Feels Like for a Girl": This song was a bit of an interesting case. The album version from 2000's Music was an intimate little trip-hop tune, while the mix for the controversial (duh!) music video (directed by Madonna's then-husband, Guy Ritchie) was an upbeat trance number.
While we happen to prefer the latter version (which you can hear above), both mixes got played in the clubs. "What It Feels Like for a Girl" topped the Dance/Club Play chart in 2001.