The victim, whose name has not been released, was shot when he attempted to stop a man from stealing a woman's purse at a gas station at Beechnut and the West Loop about 12:45 a.m., HPD says.
The woman was unhurt, and the shooter got away.
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Anyone with information in this case is urged to contact the HPD Homicide Division at 713-308-3600 or Crime Stoppers at 713-222-TIPS.